DSIP
/ 9-amino-acid peptide isolated from rabbit brain in 1977ALIAS · Delta Sleep-Inducing Peptide
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Decades of mechanistic investigation since 1977 have not identified a definitive receptor or sleep-promoting mechanism. Human sleep-efficacy evidence is inconclusive.
DSIP is a 9-amino-acid peptide isolated from rabbit brain cerebrospinal fluid during slow-wave sleep. Despite its name, the mechanism by which DSIP might promote sleep in humans remains inconclusive after decades of study.
Limited human sleep-efficacy studies; results are inconsistent. No definitive mechanism of action established. Not in pharmaceutical development.
Generally reported as well-tolerated in the limited published human studies. No long-term safety data at doses commonly sold in the research-chemical market.
Regulatory status
- FDA status:
- Not FDA-approved
The 1977 name "delta sleep-inducing peptide" reflects the conditions of discovery rather than a proven pharmacological property. Marketing claims about sleep benefits outrun the available human evidence.